Synthesis evaluation for Antimicrobial activities of new 3-substituted [aminoacyl] amino-6-halogenopyridazine and diperptide derivatives

Some 3-[N-Tos-or N-pht-aminoacyl] amino-6-chloropyridazines III-X and the corresponding 3-amino-6-bromopyridazines XIX-XXVI have been synthesized and screened for their antimicrobial activities. Hydrazinolysis of the N-phthaloyl derivatives in ethanol afforded the unprotected amino acid derivatives XI-XIV and XXVII-XXX. 3-[N-Tos- dipeptidyl] amino-6-chloropyridazines XV-XVIII and the corresponding dipeptides of 3-amino-6-bromopyridazine XXXI-XXXVI have been synthesized via the dicyclohexylcarbodiimide [DCC] method. Some of the synthesized compounds were found to possess significant antimicrobial activities towards different microorganisms

Synthesis and Antimicrobial activity of some new thiadiazole amino acid derivatives

The synthesis and antimicrobial evaluation of different 5-[N-tosyl- or N-phthaloyl- or free aminoacyl or N-tosyltripeptidyl] amino-1,2,3- thiadiazoles and the corresponding derivatives of 5-amino-4-methyl-1,2,3-thiadiazoles [III-XXVI] were described